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Total Reactions
Avg Yield %
Excellent ≥85%
High 70–85%
Moderate 50–70%
Low <50%
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# Aryl Halide Boronic Acid Catalyst Ligand Base Solvent Yield Source
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Query SMILES
Quick examples
Enter a SMILES string above and click Find Similar to search by molecular structure
How it works: Enter SMILES for your aryl halide and boronic acid, choose your conditions, then click Predict Yield. The system uses RDKit Morgan fingerprint similarity (Tanimoto) to find the closest reactions in the dataset and computes a weighted-average yield estimate. A RandomForest model trained on the full dataset provides a second independent estimate.
Load an existing reaction
Reactant SMILES
Aryl Halide
Bromobenzene 4-BrBenzonitrile 4-Bromotoluene 2-Bromopyridine 4-Bromoanisole 4-Bromoacetophenone
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Boronic Acid
Phenylboronic acid 4-MeO-phenyl BA 4-F-phenyl BA Thiophen-2-yl BA 4-NO₂-phenyl BA Naphthalene-2-BA
Reaction Conditions (optional — improves accuracy when matching known conditions)
Catalyst
Base
Solvent

⬡ Molecule Structures

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Reaction Detail